The Terps only managed 19 points in the first half against the Wolverines, a season low.
Reese started at center in place of Qudus Wahab and became the first true freshman to start a Terps men's basketball game since Donta Scott in 2019.
The Terps led by 11 at halftime, but a 30-point performance from Ron Harper Jr. dashed their hopes at a win.
Eric Ayala dropped a career-high 26 points with a double-double against the Wildcats.
The Terps clawed back from 21 points down, but were unable to complete what would have tied a program-record comeback.
The Terps fall to 0-3 in conference play after another slow start.
The Terps were no match for a massive 35-point performance from the Hawkeyes' Keegan Murray.
The Terps and the Bears finished with 44 combined fouls and Maryland's starting five combined for 79 of its 81 points.
The Terps relied on a strong night from Eric Ayala to move past the Mountain Hawks.
Fatts Russell and Eric Ayala combined for 38 points in the Terps' first win under interim head coach Danny Manning.