The Terps notched their first win in East Lansing since 1950 to improve to 4-0.
The Terps removed the full team “good-on-good” portion of its practices the last two weeks, which pits the first team offense against the first team defense.
Roman Hemby, Colby McDonald and Antwain Littleton II have powered the Terps' efficient run game.
Chambers transferred to Maryland after stops at four other schools to return home for his final college football season.
The Terps forced four turnovers after halftime in another dominant defensive effort.
The Terps scored 42 consecutive points and improved to 3-0 with a win over their interstate rivals.
The Terps deploy a collection of defensive lineman and linebackers with versatility to play multiple positions.
“In our locker room, it wasn’t necessarily a celebration,” coach Michael Locksley said after the game. “We all know we didn’t play up to our standard.”
The Terps piled on 29 points after halftime while their defense held the 49ers scoreless for much of the second half.
Hemby and Antwain Littleton II's improved pass blocking abilities will be relied on as the Terps' offensive line remains uncertain.