The Terps fell to their third consecutive loss in a lopsided fashion against the Bruins, suffering their worst ever lost at Xfinity Center.
The Terps once trailed by 21 points but had a shot to tie the game as the buzzer sounded.
The Terps fell to 8-1 after an undefeated start to the season.
The Terps took down their first ranked opponent of the year to advance to 8-0.
The Terps improve to 7-0.
Maryland's starting five has powered one of the most efficient offenses in the country so far this season despite a lack of scoring from the bench.
With the win, the Terps took home the 2022 Basketball Hall-of-Fame Tip-Off Championship crown.
The Terps will take on the winner of Miami and Providence in the championship game Sunday at 1 p.m.
Reese finished with a career-high 19 points and 12 rebounds.
The victory marked the Terps' 46th consecutive home-opener win in coach Kevin Willard's first game.