The Terps struggled to make shots early and the Wolfpack held onto their lead for all but three minutes of the game.
Owusu led her team in points and guided the Terps to victory over the Bears.
The Terps earned a major win against No. 6 Baylor, the first of three top-10 matchups during the next week.
The Terps quickly jumped out to a double-digit lead and never looked back as they blew past the Mountaineers.
Owusu appeared to roll her ankle in the third quarter after scoring 14 points for the Terps.
Angel Reese scored 21 points and grabbed 14 rebounds as the Terps pulled away from the Lancers.
The Terps dominated both Fairmont State and Georgian Court in their two exhibition matches.
Although the Terps bring back almost all of its team from a year ago, the battle for playing time is still up in the air.
Chloe Bibby sets the tone for Maryland leadership and inspires those who will succeed her.
The Terps bring back 93 percent of their offense from last season.