The Terps shot 58.6 percent from the field.
Owusu scored 13 points in the fourth quarter to propel the Terps past the Cornhuskers.
The Maryland women's basketball coach has been inspired by her father's battle with prostate cancer.
The Terps welcomed families into Xfinity Center for the first time during Saturday's regular season finale.
Five players scored in double digits for the Terps Saturday afternoon.
Ashley Owusu led the way with 22 points as the Terps picked up their ninth straight win.
The Terps have reeled off eight straight wins, all of which have been by double digits.
Though the Terps scored a season-low 62 points, they held Northwestern to just 50 points.
The Terps held the Wildcats to just 30.2 percent shooting.