The Terps couldn't pull out a win in head coach Meghan Ryan Nemzer's return to New Brunswick.
The Terps failed to get a conference win for the second consecutive season, leading to the announcement they will search for a new coach for the 2022 season.
Switching to a 4-4-2 formation didn't help the Terps, as they surrendered five goals to the Nittany Lions.
The Terps took their first point against a Big Ten opponent in seven games.
The Terps have kept three clean sheets this season after only recording one during the spring 2021 season.
Locksley opened up scoring in the first half, helping push the Terps to back-to-back wins.
The Terps were winless in the spring, but with a majority of players returning, coach Ray Leone's squad wants to show improvement.
"I think a big part of Maryland culture and being a part of the Maryland athletics family is the theme of resilience."
The Buckeyes scored three goals in the second half.
The Terps fell to Michigan for the second straight game.