The sophomore's career day helped the Terps hold off the Nittany Lions.
Mimi Collins scored a career-high 22 points to lead the Terps.
Owusu and Miller combined for 53 points against Towson, including eight three-pointers.
The Terps held the Tigers to 39% shooting.
The Terps are averaging 17.7 turnovers per game.
Katie Benzan tied a school record with eight three-pointers.
The Terps were outscored 23-9 in the third quarter.
Diamond Miller and Angel Reese tallied 20 points each for the Terps.
"Every single person can score the basketball," coach Brenda Frese said. "It's just you guys are used to the faces that scored it for us last year."
Coach Brenda Frese is working to ensure the team's recruiting pipeline continues to pay dividends in 2021 and 2022.