The Terps employed the 5-1 last season, with Alford as the lone setter.
The Boilermakers racked up seven service aces while the Terps had none.
After topping Indiana on Friday, the Terps couldn't put it together against the Boilermakers.
Hoosiers outside hitter Breana Edwards racked up 39 kills in the match.
Katie Myers and Nicole Alford are expected to miss the match against Indiana.
"This group is a great continuation of the culture we're building at Maryland."
Smith didn’t record a kill but notched three blocks.
“You probably don’t understand it until you sit in this seat, but we got out-coached tonight," Hughes said.
The Terps hit a season-low .045 in the match.
Myers was out with a foot injury sustained in practice.