The sophomore's career day helped the Terps hold off the Nittany Lions.
The Terps are the highest-ranked Big Ten team.
Six Terps scored in double figures, led by Ashley Owusu's 19 points.
The Terps only used seven players in their Big Ten opener against Rutgers.
Reese was the No. 2 recruit in the country entering the season.
Reese was named the Big Ten's Co-Freshman of the Week, while Katie Benzan was also honored.
Katie Benzan tied a school record with eight three-pointers.
All six former Terps in the WNBA made the playoffs.
Charles will go down as one of the all-time greats for Maryland women's basketball.