Lowe leads the Tampa Bay Rays with 16 home runs and 49 RBI.
The former Maryland pitching standout made his MLB debut Friday night, after being called up on May 30.
The former Terrapin standout has been called up to the MLB for the first time in his professional career.
Right-hander Elliot Zoellner pitched 3 1/3 scoreless innings of relief, but the Terps faltered late.
Weather forced Thursday's game to continue on Friday morning.
Right-hander Hunter Parsons allowed just one run in 7 1/3 innings.
Lee started 4-for-27, but is now hitting a team-best .301.
The Terps swept the Hawkeyes to ensure their season continues.
The Terps can clinch a spot in the Big Ten tournament with a win Saturday.
The Terps allowed four runs in the ninth, but AJ Lee's walk-off home run ended it.