The Terps managed to hold onto its lead despite challenge from the Golden Gophers' Jamison Battle who finished with 39 points.
Ayala and Russell combined for 50 points against the ranked Buckeyes and Russell broke 2,000 points in his career.
The Terps had six players score double-digits, led by Fatts Russell with 23 points.
Despite keeping the game close against No. 3 Purdue, the Terps fell to 11-14 on the season with its fifth straight defeat.
With the potential for a last-second upset victory, the Terps couldn't pull out the win over the Boilermakers.
The freshman walk-on is bringing life to the Terps' bench and giving his all on the practice court.
The Terps kept pace with the Hoosiers in the opening half, but were quickly outmatched in the second, dropping a crucial Big Ten game.
The Terps' 68-60 win over Rutgers was their third win against a conference opponent the second time of playing them.
The Terps won their second consecutive conference game for the first time this season and handed the Scarlet Knights their second loss at home.
After starting the game on the bench for the first time all season, Scott led all scorers with 25 points.