The Terps were no match for a massive 35-point performance from the Hawkeyes' Keegan Murray.
The Terps had a full week between games and were able to benefit from extra practice time.
The Terps trailed at the half for the fifth time at home this season and were unable to hold the lead they gained early in the second period.
The Cardinals out-rebounded the Terps to put the championship trophy out of reach.
The Terps relied on a group of smaller players against Hofstra, including first-year Maryland players Martinez and Reese.
The Terps and the Pride went back and forth until the final seconds.
Schwartz dropped 24 points on the Terps in the program's first loss to George Mason.
The Terps found themselves down at the half for the third straight game, but were unable to come away with a win against the Patriots.
The Terps and Catamounts played a physical and tense game, amassing fouls and clashing after plays.
The Terps' starting shooting guard notched his milestone 1,000th point on a free throw in the first half and helped Maryland to a season-opening win.