Owusu appeared to roll her ankle in the third quarter after scoring 14 points for the Terps.
Mila Reynolds and Ava Sciolla will join the program next fall.
Angel Reese scored 21 points and grabbed 14 rebounds as the Terps pulled away from the Lancers.
Although the Terps bring back almost all of its team from a year ago, the battle for playing time is still up in the air.
Chloe Bibby sets the tone for Maryland leadership and inspires those who will succeed her.
The Terps bring back 93 percent of their offense from last season.
Owusu was held scoreless in the fourth quarter in the Terps' season-ending loss to Texas.
The Terps scored their fewest points all season as they were bounced in the Sweet 16.
Brenda Frese's squad tallied 22 assists on 42 made shots.
The Terps held the Mountaineers to four points on 12.5 percent shooting in the second quarter.