The Terps' dominant first-half performance secured them a win after the Nittany Lions battled in the second.
Led by Chloe Bibby, the Terps finished out a two-game home stand undefeated.
The Terps are midway through their conference schedule with a below standard 5-3 record against Big Ten teams.
Dominant performances from Katie Benzan and Ashley Owusu brought the Terps back into the win column.
Mikesell scored a career-high 33 points against her former team and went 5-for-5 from three.
With the loss, the Terps' 31-game home winning streak came to an ugly end.
In the Terps' ever-changing starting five, Bibby's success in the two forward spots has been a constant.
The Terps scored 22 points off of Golden Gopher turnovers.
Miller and Owusu combined for 44 points in Miller's first start of the season.
The Terps lost to the Hoosiers for the first time in program history.