The Terps dominated in both sides of the game as they launched seven homers and Sean Burke put together a strong start.
Despite the senior day loss, the Terps are still in prime position to make the NCAA tournament.
Terps right-hander Zach Thompson allowed four runs over four innings.
After posting just five runs in three games against Coastal Carolina, the Terps were potent on Wednesday.
“We’ve just got to make sure we treat those as just as important as the weekend games."
The Patriots issued 14 walks, hit four batters and threw three wild pitches.
Right-hander Elliot Zoellner pitched 3 1/3 scoreless innings of relief, but the Terps faltered late.
Weather forced Thursday's game to continue on Friday morning.
Right-hander Hunter Parsons allowed just one run in 7 1/3 innings.
Lee started 4-for-27, but is now hitting a team-best .301.