Angel Reese led the Terps in the score column and Chloe Bibby notched her 1,000th career point against the Wildcats.
Qudus Wahab led the team in points for the second consecutive game and he clocked his first double-double in a Maryland uniform.
Wahab led the Terps in points in their season opener Tuesday night with 17.
The Terps dominated both Fairmont State and Georgian Court in their two exhibition matches.
Maryland is looking for its first Elite Eight appearance since 2015.
Alabama has struggled to end the season, losing seven of its final 11 games.
The Terps are looking to make the Sweet Sixteen for the first time since 2017.
Alabama won both the SEC regular-season and conference tournament championships.
The Terps are looking for their first Sweet Sixteen appearance since 2016.
The Terps have never lost in the first round under Brenda Frese.