Dominant performances from Katie Benzan and Ashley Owusu brought the Terps back into the win column.
Mikesell scored a career-high 33 points against her former team and went 5-for-5 from three.
Briggs suffered a season-ending injury after competing in 14 games for Florida, but will join the Terps for the 2022-23 season.
With the loss, the Terps' 31-game home winning streak came to an ugly end.
In the Terps' ever-changing starting five, Bibby's success in the two forward spots has been a constant.
The Terps scored 22 points off of Golden Gopher turnovers.
Miller and Owusu combined for 44 points in Miller's first start of the season.
The Terps lost to the Hoosiers for the first time in program history.
Katie Benzan dropped a team-high 22 points in the Terps' first game in nine days.
The Terps struggled offensively against the Gamecocks who pulled down 61 rebounds.