The Terps rallied in the middle of the game to take a one-run lead into the bottom of the ninth, but were defeated by the Commodores.
The Terps have now four of their last six games.
Savacool struck out nine across seven innings and gave up just two runs.
The Terps take on the defending champion Rebels in a series that could serve as an early-season measuring stick for the rising program.
The Terps gave up five runs in the first inning as they suffered their second loss of the season.
Dean dazzled in his season debut, pitching six scoreless innings and striking out eight.
Savacool gave up five earned runs across six innings.
The Terps are coming off a record-setting season where they claimed a Big Ten title and hosted a regional for the first time in program history.
Dean battled injury last season, while Savacool found his form.