Regan Kerr's first inning solo shot was one of just two hits for the Terps.
The Terps cruised in the first game and walked off the Spartans in the second contest.
The Terps' bats fell quiet in game one but roared to life in game two for a mercy-rule victory.
The Terps lost their third straight game by at least eight runs.
It will be the first time coach Mark Montgomery will play a game in the state of Maryland.
A four-run fifth inning sent the Terps to victory in the first game of the doubleheader, while the Boilermakers walked it off in game two.
Infielder Taylor Okada went 4-for-5 with three RBI.
Montgomery led Louisiana Tech to 30 or more wins in each of the past five seasons.
The Terps are slated to take on Pittsburgh and Clemson in February.
The Terps had their best start since 2015, but results began falling off in Big Ten play.