The Terps missed each of their last 10 shots against the Nittany Lions.
Ayala tied a career-high with 23 points, but the Terps failed to make a field goal in the last 7:32 of the game.
Wiggins scored a team-high 18 points against Purdue on Feb. 2.
Ayala is a steadying presence for an inconsistent Maryland offense.
Ayala and Wiggins combined for 25 of the Terps' 37 points in the second half.
The Terps dance to "Grove St. Party" before every home game.
The Terps coughed the ball up four times in a three minute stretch in the second half, halting their comeback efforts.
The Terps trailed as much as 18 in the game.
“We accepted who we are and what we’re going to be about."
Wiggins' production has increased across the board this season.