The Terps committed a season-high 20 turnovers in the loss.
Julian Reese and Pat Emilien both fouled out while Michigan center Hunter Dickinson scored 32 points Sunday.
The Terps suffered their largest conference defeat since joining the Big Ten and fell to 10-4 as Dickinson and the Wolverines dominated coach Kevin Willard's squad.
The Terps overcame a strong showing from their in-state adversary.
Ian Martinez and Patrick Emilien replaced Don Carey and an injured Julian Reese in the starting lineup as coach Kevin Willard tinkered with the Terps' starters and rotations against the Peacocks.
The Terps coasted to a comfortable victory following an extended break.
The Terps fell to their third consecutive loss in a lopsided fashion against the Bruins, suffering their worst ever lost at Xfinity Center.
The Terps made just two of their 24 three-pointers against the Volunteers.
The Terps once trailed by 21 points but had a shot to tie the game as the buzzer sounded.
The Terps notched only nine points in transition — their third lowest total of the season.