Reese started at center in place of Qudus Wahab and became the first true freshman to start a Terps men's basketball game since Donta Scott in 2019.
The Terps led by 11 at halftime, but a 30-point performance from Ron Harper Jr. dashed their hopes at a win.
Eric Ayala dropped a career-high 26 points with a double-double against the Wildcats.
The Terps fall to 0-3 in conference play after another slow start.
The Terps were no match for a massive 35-point performance from the Hawkeyes' Keegan Murray.
The Terps had a full week between games and were able to benefit from extra practice time.
The Terps trailed at the half for the fifth time at home this season and were unable to hold the lead they gained early in the second period.
The Cardinals out-rebounded the Terps to put the championship trophy out of reach.
The Terps relied on a group of smaller players against Hofstra, including first-year Maryland players Martinez and Reese.
The Terps and the Pride went back and forth until the final seconds.