The Terps gave up seven runs in the third inning to fall into an early hole they couldn't climb out of.
Savacool struck out nine across seven innings and gave up just two runs.
The Terps take on the defending champion Rebels in a series that could serve as an early-season measuring stick for the rising program.
The Terps gave up five runs in the first inning as they suffered their second loss of the season.
Dean dazzled in his season debut, pitching six scoreless innings and striking out eight.
Savacool gave up five earned runs across six innings.
The Terps are coming off a record-setting season where they claimed a Big Ten title and hosted a regional for the first time in program history.
Dean battled injury last season, while Savacool found his form.
The Terps ended the season with a disappointing semifinal loss and haven't won the NCAA title since 2011.
The Terps fell in the national tournament semifinal for the second consecutive season.