The Terps lost their third straight game by at least eight runs.
The Terps exploded late in the first game for a six-run victory, while the Buckeyes won on mercy rule in the second contest.
The Terps managed just three hits against the Buckeyes' Allison Smith.
Lindy Milkowski hit a walkoff for the Hawkeyes.
Trinity Schlotterbeck led the way for the Terps, striking out 12 batters and posting a 0.63 ERA in the opening weekend.
Jaeda McFarland's walk-off single pushed the Terps to 3-3 on the season.
Taylor Okada drove in the game winning run in extra innings to salvage a 1-1 set against the Fighting Illini.
The Terps sport a slew of new faces and are looking to build off a pandemic-shortened 12-11 campaign.
Schlotterbeck is the first player in program history to earn Big Ten Freshman of the Week honors.