With Reese potentially out until March, Mimi Collins and Faith Masonius are being called upon to replicate her impact.
Diamond Miller was also named to the Big Ten Player of the Week Honor Roll.
Owusu and Miller combined for 53 points against Towson, including eight three-pointers.
Reese was the No. 2 recruit in the country entering the season.
The Terps held the Tigers to 39% shooting.
The Terps are averaging 17.7 turnovers per game.
The pair combined to hit 19 threes in the opening three games of the season.
Reese was named the Big Ten's Co-Freshman of the Week, while Katie Benzan was also honored.
Katie Benzan tied a school record with eight three-pointers.
The Terps were outscored 23-9 in the third quarter.