The Terps dominated in both sides of the game as they launched seven homers and Sean Burke put together a strong start.
The Terps struggled to keep the 49ers silent, allowing runs in six straight innings.
"We feel very confident that we can go in there and make some noise in this thing."
The Terps are the No. 3 seed in the Greenville Region and will face Charlotte on Friday.
Despite the senior day loss, the Terps are still in prime position to make the NCAA tournament.
The Terps walked off the Hoosiers in the first game, while Sean Burke took a no-hitter into the seventh inning of game two.
The Terps slot in at No. 25 nationally.
The Terps now sit tied for second place in the Big Ten.
The Terps struggled to halt the Wolverines' powerhouse offense and their bats ran cold until it was too late.
Matt Orlando's double in the eleventh inning and six straight strikeouts from Ryan Ramsey set the Terps up for a monumental win.