Maxwell Costes hit the go-ahead single in the seventh.
The Terps outscored the Boilermakers 21-12 in the final period.
Charles fueled Maryland's comeback win over Minnesota.
After managing just two points against Iowa on Feb. 17, Charles shined Thursday.
The Terps went on a 9-0 run in the final 50 seconds.
"When was the last time you see her not hitting open jumpers?”
Gustafson poured on 24 second-half points, including 10 from the free-throw line.
The Terps eight-game win streak was snapped by Iowa on Sunday.
Hawkeyes forward Megan Gustafson scored 24 second-half points.
"She’s an All-American for a reason."