Mikesell scored a career-high 33 points against her former team and went 5-for-5 from three.
The Terps were swept by the Buckeyes for the second time this season and were dealt their third-straight loss at home.
The Terps will finish the regular season in Ohio State with some spring in their step.
The Terps are hopeful after their loss to Penn State earlier this week.
The Terps have a chance to beat the Buckeyes on senior night.
The Terps had two 6-0 runs during Saturday's game.
Voluntary football workouts have been suspended.
Guard Ashley Owusu led the way with 17 points, six rebounds and 11 assists.
The Terps have lost three of their last four games.
The Buckeyes corralled 13 offensive rebounds and had 14 second-chance points.