Anna Kufta clubbed a two-run homer against the Thunderbirds.
The Terps are entering on the back of three wins in four games last weekend.
The Terps took three of their four games at the Eagle Round Robin.
Wyche threw 15 strikeouts and allowed just one hit.
The Terps earned their second consecutive win for the first time this season.
Infielder Taylor Okada went 4-for-5 with three RBI.
The Tigers handed the Terps their worst loss of the season, a 21-2 drubbing.
Outfielder Campbell Kline finished with two of the Terps' seven hits.
They'll have a chance to redeem themselves in the ACC/Big Ten Challenge this weekend.
The Terps struck first but couldn't hang on.