Jahmir Young's 26 points and Julian Reese's 20-point double-double led the Terps to a their first ranked win of the year.
Julian Reese bounced back from his recent struggles, but the Terps fell to 3-12 on the road under Kevin Willard.
The Terps' three-point struggles allowed the Boilermakers to clog the lane and make life harder for Julian Reese, who didn't score on Tuesday.
The Terps' 20-point second half lead dwindled to just two late, but Young lifted Maryland to its fourth straight victory.
The Terps scored their most points in a game since 2011 and made 14 three-pointers in Tuesday's victory.
Julian Reese and Jahmir Young have combined to make up 48 percent of the Terps' scoring so far this season.
The Terps fell to 1-10 on the road against Big Ten opponents under coach Kevin Willard.
After three straight wins in College Park, the Terps will go on the road to take on 5-1 Indiana on Friday.
The Terps scored 100 points in a game for the first time since January 2021, and the for first time against a Division I opponent since 2018.