The Terps beat the Huskies for the first time in program history.
Sellers' shot dropped as time expired to give the Terps the win.
The Terps have followed up wins over ranked teams with losses to unranked opponents multiple times already this season.
Diamond Miller, Brinae Alexander and Abby Meyers each had four fouls in the blowout loss.
The Terps could not get head coach Brenda Frese her 600th career win in their Big Ten opener.
Miller became the first player with a 30-point, 10-rebound, five-assist game since Alyssa Thomas in 2013.
Miller's midrange jump shot at the buzzer lifted the Terps over the Fighting Irish.
The Terps went 2-1 at the Fort Myers Tip-Off over the Thanksgiving holiday.
Abby Meyers led all scorers with 23 points.
The Terps rebounded from a loss to DePaul on Friday with a win over the Tigers.