The Terps led by 11 at halftime, but a 30-point performance from Ron Harper Jr. dashed their hopes at a win.
Eric Ayala dropped a career-high 26 points with a double-double against the Wildcats.
The Terps clawed back from 21 points down, but were unable to complete what would have tied a program-record comeback.
The Terps fall to 0-3 in conference play after another slow start.
College basketball's leading scorer dropped 35 points after a slow night on defense for the Terps.
The Terps were no match for a massive 35-point performance from the Hawkeyes' Keegan Murray.
The Terps and the Bears finished with 44 combined fouls and Maryland's starting five combined for 79 of its 81 points.
The Terps relied on a strong night from Eric Ayala to move past the Mountain Hawks.
The Terps had a full week between games and were able to benefit from extra practice time.
Fatts Russell and Eric Ayala combined for 38 points in the Terps' first win under interim head coach Danny Manning.