Bibi Donraadt netted two goals as the Terps dispatched the Eagles.
The Terps crushed their second conference opponent in their biggest win since 2019.
The Terps topped the Tigers in overtime for the fourth consecutive time.
"The outcome of this is very disappointing for our group," Terps coach Missy Meharg said.
The Terps commanded both sides of the field to shut out Duke for the first time since 2012.
The Terps dropped their first game of the season.
The Terps will meet former conference rivals in Duke and Boston College over the weekend.
A diving save from Bibi Donraadt kept the Terps alive.
"If you can't battle with each other off the field, then there's no way you're going to do it for each other on the field."
Coach Missy Meharg brought on two former Terps in Kasey Tapman Asper and Sarah Holliday, and the Canadian men's international team captain Scott Tupper.