The freshman duo combined for 29 points on 11-for-20 shooting.
Freshmen guards Diamond Miller and Ashley Owusu combined for 33 points.
While the Terps mounted a comeback in the third frame, they couldn't finish it off.
Charles poured in a season-high 28 points.
The Terps had season-highs in turnovers (24) and fouls (26).
Charles notched a double-double with 23 points and 11 rebounds.
Blair Watson and Taylor Mikesell each had 23 points.
The Terps went 1-1 on the week, falling to the Wolfpack and dominating Loyola.
Mikesell hit six 3-pointers, a new career high.