Down three starting cornerbacks, the Terps let C.J. Stroud throw for over 400 yards as the Buckeyes put up 66 points.
The Terps will turn to their depth as they try to upset the Buckeyes.
The star wide receiver will need knee surgery after suffering a gruesome injury Friday against Iowa.
The Terps committed seven turnovers as they could not keep up with the Hawkeyes.
With the help of defensive back Kenny Bennett, Brade has adapted to the college game.
The Terps had 12 pass catchers in the win over the Golden Flashes.
Tagovailoa has 956 passing yards, seven passing touchdowns and no interceptions in the season's first three games.
The Terps reached 3-0 for the first time since 2016 in pulling out a scrappy, ugly victory over the Fighting Illini.
The tight end and quarterback have connected for two red-zone touchdowns in two games.